From Bench to Bedside: The Evolution of Tissue-engineered Maxillofacial Reconstruction – Conceptualizing the practicality of in-situ tissue engineering for our patients in the modern era
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First conceptualized by W.T. Green in the 1970s, the advent of tissue engineering was a significant milestone in the field of medicine and surgery. What started as proof-of-concept studies in preclinical models has transitioned to clinically applicable regenerative strategies for maxillofacial reconstruction in patients. Tissue-engineered bone grafts have made the reconstruction of defects of the oral and maxillofacial region predictable and reliable without the need for harvesting autogenous bone. The focus of this session will be on the two fields where the most significant advancements have occurred, craniofacial bone and sensory nerves. Multiple long-term clinical studies have demonstrated tissue-engineered bone grafts and allogeneic nerve reconstruction are equivalent or even superior to autogenous grafts. The "bench" part of this session will introduce and discuss the science regarding bone and nerve repair and regeneration. The "bedside" session will focus on key concepts for the successful clinical application of tissue engineering science to bone and nerve repair. This session will briefly discuss preoperative workup, preparation, and procedural options for patients with tumors, post-resection defects, and traumatic defects. Focus areas will include surgical technique, postoperative care and the management of complications.
Learning Objectives
At the conclusion of this program, participants should be able to:
- Discuss the science behind bone grafts, tissue-engineering graft, allogeneic nerve regeneration.
- Review surgical techniques to optimize bone and nerve regeneration and patient outcomes.
- Discuss surgical technique and management of complications.
James C. Melville, DDS FACS
Associate Professor of Oral and Maxillofacial Surgery
Bernard & Gloria Pepper Katz Department of Oral & Maxillofacial Surgery, Oral & Head and Neck Oncology and Microvascular Reconstructive Surgery University of Texas Health Science Center at Houston
Houston, Texas
Disclosure: AxoGen Inc (Individual(s) Involved: Self): Consultant/Advisory Board; Integra LifeSciences (Individual(s) Involved: Self): Consultant/Advisory Board; Johnson & Johnson (Individual(s) Involved: Self): Consultant/Advisory Board; Proteocyte Diagnostics (Individual(s) Involved: Self): Consultant/Advisory Board
Simon W. Young, DDS, MD, Ph.D
Associate Professor
Bernard & Gloria Pepper Katz Department of Oral & Maxillofacial Surgery, Director of Research
Houston, Texas
Disclosure: KLS Martin (Individual(s) Involved: Self): Research Grant; Privo Technologies (Individual(s) Involved: Self): Research Grant; Proteocyte Diagnostics (Individual(s) Involved: Self): Consultant/Advisory Board; Stryker Craniomaxillofacial Inc. (Individual(s) Involved: Self): Research Grant
An Internet-based CDE/CME Activity
Original Release Date: September 12, 2022
Review Date: April 12, 2025
Expiration Date: April 12, 2028
Estimated time to complete this educational activity: 1.0 hours
Method of participation: Self-Study
James C. Melville, DDS, FACS
Associate Professor
University of Texas Health Science Center at Houston
James C. Melville, DDS, FACS, is a Professor in the Bernard and Gloria Pepper Katz Department of Oral and Maxillofacial Surgery at the University of Texas Health Science Center at Houston (UTHealth). He specializes in oral, head and neck oncology and microvascular reconstructive surgery. He earned his DDS from University of Michigan and completed a genearl practice residency at the University of California, San Francisco, followed by an oral and maxillofacial surgery residency and fellowships in oncology and microvascular reconstruction at the University of Miami/Jackson Memorial Hospital. Dr. Melville was appointed oral and maxillofacial surgery internship director at UTHealth in 2017 and has received several honors from AAOMS, including the Faculty Educator Development Award in 2019 and the Clinical Research Award in 2023. He served as the President of the Oral and Maxillofacial Section of the American Association for Dental, Oral, and Craniofacial Research (AADOCR)/International Association of Dental Research and was a scientific committee member for the International Academy of Oral Oncology conference. He is a Diplomate and examiner of ABOMS. Dr. Melville has lectured at more than 20 academic institutions, authored over 80 peer-reviewed articles, contributed to 35 textbook chapters and written five textbooks. He serves as a peer reviewer for multiple leading journals.
Disclosure(s): No relevant disclosure to display
Simon Young, DDS, MD, PhD, FACS
Associate Professor, Director of Research
University of Texas Health Science Center at Houston
Simon Young, DDS, MD, PhD, FACS, is Associate Professor and Director of Research in the Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, School of Dentistry. He completed his DDS at the Faculty of Dentistry, University of Toronto, in 2003, his PhD at Rice University, Department of Bioengineering, Houston, Texas, in 2008, and his MD at University of Texas Medical School at Houston in 2011. He subsequently completed first an Oral & Maxillofacial Surgery Residency at University of Texas Health Science Center at Houston and then a Postdoctoral Research Fellowship in Immuno-Engineering at Harvard University, School of Engineering and Applied Sciences. Dr. Young is a Diplomate of the American Board of Oral and Maxillofacial Surgery. He is the author of over 40 articles in peer-reviewed journals and has an NIH-funded laboratory that studies biomaterials-based cancer immunotherapies and maxillofacial tissue engineering.
Disclosure(s): Amend Surgical: Consultant (Ongoing); KLS Martin: Research Grant or Support (Ongoing); Proteocyte AI, Toronto: Consultant (Ongoing)
Continuing Education Provider Approval
The American Association of Oral and Maxillofacial Surgeons is an ADA CERP Recognized Provider.
ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education.
ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.
The American Association of Oral and Maxillofacial Surgeons designates this activity for 1.0 continuing education credit(s).
AGD - Accepted Program Provider
FAGD/MAGD Credit
11/1/22-12/31/26
Provider ID# 214680
The American Association of Oral and Maxillofacial Surgeons (AAOMS) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
The American Association of Oral and Maxillofacial Surgeons designates this internet-based enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
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