Maxillofacial Tissue Engineering 101: From Pediatrics to Geriatrics, Optimizing Regenerative Surgical Techniques

With the advancements made in regenerative medicine, tissue-engineered bone grafts have made the reconstruction of defects of the oral and maxillofacial region predictable and reliable without the need for harvesting autogenous bone. Long-term clinical studies have shown this mixture to be equivalent to or superior to avascular autogenous bone graft. This session will give a brief synopsis of the preoperative workup, preparation and procedural options for patients with congenital defects, benign tumors, post-resection defects and traumas. In addition, the speakers will briefly review initial evaluation, patient selection and state-of-the-art science regarding growth factors and autogenous bone substitutes. Emphasis will be placed on surgical technique, postoperative care and management of complications.

Learning Objectives

At the conclusion of this program, participants should be able to:

  1. Evaluate patients for grafts best suited for their defects (avascular bone vs. tissue engineered allogenic bone vs. microvascular free flap). 
  2. Discuss the science behind bone grafts and tissue-engineering reconstruction specifically for the maxillofacial region. 
  3. Review surgical technique and management of complications.

Michael R. Markiewicz, DDS, MD, MPH, FACS
Professor and Chair
University of Buffalo
Buffalo, New York
Disclosure(s): Axogen: Consultant (Ongoing); Synthes: Consultant (Ongoing)

James C. Melville, DDS, FACS
Associate Professor
University of Texas Health Science Center at Houston
Houston, Texas
Disclosure(s): AxoGen, Inc.: Consultant (Ongoing); Proteocyte AI, Toronto: Consultant (Ongoing)

Simon Young, DDS, MD, PhD, FACS
Associate Professor, Director of Research
University of Texas Health Science Center at Houston
Houston, Texas
Disclosure(s): Amend Surgical: Consultant (Ongoing); KLS Martin: Research Grant or Support (Ongoing); Proteocyte AI, Toronto: Consultant (Ongoing)

An Internet-based CDE/CME Activity
Original Release Date: September 23, 2023
Expiration Date: September 23, 2026
Estimated time to complete this educational activity: 1.0 hours
Method of participation: Self-Study

Michael R. Markiewicz, DDS, MD, MPH, FACD, FAAP, FACS

Professor and Chair

University of Buffalo

Dr. Markiewicz is Professor and Chair of the Department of Oral and Maxillofacial Surgery at the University of Buffalo, and adjunct Professor in the Departments of Neurosurgery and Surgery at the Jacob’s School of Medicine and Biomedical Science. He is an attending Head and Neck and Reconstructive Surgeon and Roswell Park Cancer Center, and is Co-director of the Cleft and Craniofacial Team, at the Craniofacial Center of Western New York. Dr. Markiewicz earned his Dental Degree at the University at Buffalo, and Medical Degree at Oregon Health and Science University where he also completed his General Surgery and Oral and Maxillofacial Surgery training. He obtained a Master’s of Public Health from Harvard University with a concentration in Biostatistics and Epidemiology, and completed a Fellowship in Clinical Investigation at The Massachusetts General Hospital, Boston Massachusetts. Dr. Markiewicz completed a fellowship in Pediatric Cleft and Craniomaxillofacial Surgery, at the Arnold Palmer Hospital for Children, in Orlando Florida. To complete his surgical training, he completed a fellowship in Head and Neck Oncologic and Microvascular Reconstructive Surgery in the Division of Head and Neck Surgery, at the University of Florida, College of Medicine, in Jacksonville Florida. Dr. Markiewicz’s clinical and research interests are dedicated to the management of Cleft and Craniofacial anomalies in Children and Adults, the treatment of Head and Neck Cancer, and the reconstruction of Congenital and Acquired Defects in Children and Adults.

Disclosure(s): Axogen: Consultant (Ongoing); Synthes: Consultant (Ongoing)

James C. Melville, DDS, FACS

Associate Professor

University of Texas Health Science Center at Houston

James C. Melville, DDS, FACS, is an Associate Professor in the Department of Oral and Maxillofacial Surgery at the University of Texas Health Science Center at Houston UTHealth and specializes in Oral, Head & Neck Oncology, and Microvascular Reconstructive Surgery. He graduated from the University of Michigan School of Dentistry in Ann Arbor, Michigan, in 2005 and completed a General Practice Residency at the University of California San Francisco in 2006. He completed a residency in oral and maxillofacial surgery in 2012, followed by fellowships in oral, head, and neck oncology and microvascular reconstructive surgery at the University of Miami/Jackson Memorial Hospital. He was appointed to the UTH OMFS internship director in 2017.

Dr. Melville was awarded the Faculty Educator Development Award (FEDA) in 2019 by the American Association of Oral & Maxillofacial Surgeons (AAOMS). An award given to promising young academic surgeons. He was awarded the AAOMS Advocacy Challenge Coin by the AAOMS Board of Trustees and AAOMS Committee on Government Affairs in 2020. AAOMS designed its own Challenge Coin to recognize oral and maxillofacial surgeons who have made significant advocacy contributions on behalf of the Association. The AAOMS Challenge Coin is awarded to those elite few who transcend the efforts of their colleagues to further the specialty through advocacy. Dr. Melville serves as the Vice-President of the Oral & Maxillofacial Section of the American Association for Dental, Oral, and Craniofacial Research (AADOCR) / International Association of Dental Researchers (IADR) and will be become the President in 2023. He was appointed the Vice President of the AAOMS Clinical Interest Group (CIG) in Neurologic Disorders 2021. He also serves on the International Academy of Oral Oncology (IAOO) as a scientific committee member for its 2022 conference.

Dr. Melville is a diplomate and examiner of the American Board of Oral and Maxillofacial Surgery and a fellow of the American Association of Oral and Maxillofacial Surgeons, the American Academy of Craniomaxillofacial Surgeons, American College of Oral & Maxillofacial Surgeons, and the American College of Surgeons. He has been an invited visiting professor and lecturer at over 15 academic institutions including Case Western University, Columbia University, Harvard/MGH, Emory University, Johns Hopkins University, University of Michigan, UOP/ Stanford University UCLA, USC, and UCLA.

He has written a Springer textbook on maxillofacial reconstruction and contributed to 25 chapters in textbooks concerning oral and maxillofacial surgery, oncology, maxillofacial reconstruction, microvascular reconstruction, and tissue engineering. In addition, he is the author of more than 40 articles in peer-reviewed journals. He is a reviewer for the Journal of Oral and Maxillofacial Surgery (JOMS), Triple OOOO Journal, Journal of Cranio-Maxillofacial Surgery, Journal of Tissue Engineering, PLOS ONE, Bioengineering & Translational Medicine (Wiley), Journal of Biomedical Materials Research, Experimental Dermatology, Japanese Dental Science Review, and of Journal of American Dental Association (JADA).

Disclosure(s): AxoGen, Inc.: Consultant (Ongoing); Proteocyte AI, Toronto: Consultant (Ongoing)

Simon Young, DDS, MD, PhD, FACS

Associate Professor, Director of Research

University of Texas Health Science Center at Houston

Simon Young, DDS, MD, PhD, FACS, is Associate Professor and Director of Research in the Department of Oral and Maxillofacial Surgery, The University of Texas Health Science Center at Houston, School of Dentistry. He completed his DDS at the Faculty of Dentistry, University of Toronto, in 2003, his PhD at Rice University, Department of Bioengineering, Houston, Texas, in 2008, and his MD at University of Texas Medical School at Houston in 2011. He subsequently completed first an Oral & Maxillofacial Surgery Residency at University of Texas Health Science Center at Houston and then a Postdoctoral Research Fellowship in Immuno-Engineering at Harvard University, School of Engineering and Applied Sciences. Dr. Young is a Diplomate of the American Board of Oral and Maxillofacial Surgery. He is the author of over 40 articles in peer-reviewed journals and has an NIH-funded laboratory that studies biomaterials-based cancer immunotherapies and maxillofacial tissue engineering.

Disclosure(s): Amend Surgical: Consultant (Ongoing); KLS Martin: Research Grant or Support (Ongoing); Proteocyte AI, Toronto: Consultant (Ongoing)

Continuing Education Provider Approval
The American Association of Oral and Maxillofacial Surgeons is an ADA CERP Recognized Provider.

ADA CERP is a service of the American Dental Association to assist dental professionals in identifying quality providers of continuing dental education.

ADA CERP does not approve or endorse individual courses or instructors, nor does it imply acceptance of credit hours by boards of dentistry.

The American Association of Oral and Maxillofacial Surgeons designates this activity for 1.0 continuing education credit(s).

AGD - Accepted Program Provider
FAGD/MAGD Credit
11/1/22-12/31/26
Provider ID# 214680

The American Association of Oral and Maxillofacial Surgeons (AAOMS) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The American Association of Oral and Maxillofacial Surgeons designates this internet-based enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Key:

Complete
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Faculty and Planner Disclosure
Pre-Quiz
3 Questions  |  1 attempt  |  0/3 points to pass
3 Questions  |  1 attempt  |  0/3 points to pass
Maxillofacial Tissue Engineering 101: From Pediatrics to Geriatrics, Optimizing Regenerative Surgical Techniques
Open to view video.
Open to view video.
Post-Quiz
3 Questions  |  Unlimited attempts  |  2/3 points to pass
3 Questions  |  Unlimited attempts  |  2/3 points to pass
Evaluation
11 Questions
Certificate
1.00 CDE/CME credit  |  Certificate available
1.00 CDE/CME credit  |  Certificate available